We used our previously described immunocompetent mouse model of ATC in which 105 genetically engineered murine ATC; TBP 3743 BRAFV600E/WT P53−/− cells are implanted into an immunocompetent mouse thyroid, resulting in a very rapidly enlarging tumor with marked infiltration of CD8+ T lymphocytes when treated with PLX4720 [29]. The gene discussed is CD8A; the disease is neoplasm.