Our studies did show that PD-L1 blockade has very minimal effects on the tumor when given alone, despite fairly impressive infiltration of CD8+ T cells and high activity of Granzyme B. This finding is not entirely unexpected, however, given the aggressiveness of this specific ATC model in which more conventional agents such as BRAF or Src inhibitors were less effective [35]. The gene discussed is CD274; the disease is neoplasm.