Loy et al. [7] reported that the vast majority of colon cancers (80 %) are CK7 (−)/CK20 (+) while some (16 %) are CK7 (+)/CK20 (+) and a few (4 %) are CK7 (−)/CK20 (−). This evidence concerns the gene KRT20 and malignant colon neoplasm.