In immunohistochemical analysis, stromal tumours are usually diagnosed as myogenic (i.e. leiomyomas or leiomyosarcomas) when they are diffusely positive for desmin or smooth muscle actin, as neurogenic when positive for S-100 protein or as gastrointestinal stromal tumours (GIST) when positive for CD117 (c-kit) [37]. The gene discussed is DES; the disease is leiomyosarcoma.