The histopathological diagnosis was as follows: invasive ductal carcinoma, scirrhous carcinoma, nuclear grade 2, positive for lymph node metastasis (1/16), ER: positive, PgR: negative, HER2/Neu: negative (1+ on immunohistochemistry), Ki67: <5, phenotype: luminal A, pTNM stage: T1cN1M0 stage IIA. This evidence concerns the gene ESR1 and scirrhous adenocarcinoma.