Interestingly, we observed that the mitophagy deficit seemed correlated with abnormal tau accumulation, i.e., the increase of COX IV and TOMM20 was only shown in those AD patients who had high level of tau proteins (AD group), not AD patients (AD1 group) whose total tau had no significant change compared with the nondemented control (Figure 1A-1C). The gene discussed is COX4I1; the disease is Alzheimer disease.