Altogether, diet with pterostilbene supplementation or daily pterostilbene injections in Pten+/f and Ptenf/f immunocompetent pre-clinical mouse models, respectively, reduced the profoundly elevated MTA1 levels and inhibited the coordinate expression of multiple components of MTA1 tumor-promoting signaling, demonstrating the in vivo efficacy of pterostilbene as a MTA1-targeted chemopreventive and intervention strategy. Here, PTEN is linked to neoplasm.