Since several factors and cytokines, including NF-κB (p65), IL-1β, and Hsp90 have been implicated either in MTA1 regulatory network or induction of reactive stroma or both [32–34], we found that concomitant with MTA1, the expression of these proteins was increased with continued tumor development (Figure 1E), suggesting a pro-inflammatory role for MTA1 in both the tumor and reactive stroma. Here, IL1B is linked to neoplasm.