In the Ptenf/f (Pten-null) mice, which mimic stage-defined progression of human prostate cancer [23], we found an age-dependent increase in MTA1 expression along with expected increased levels of p-Akt as compared to their normal counterparts (Figure 1D and 1E), suggesting a strong correlation with the progression of prostate cancer. This evidence concerns the gene PTEN and prostate carcinoma.