All mice by 8–10 months of age developed high grade PIN, however mice on PTER-diet showed 50% reduction in the number of glands involved in PIN (Figure 4B and Supplementary Table S2) and more favorable histopathology with restored normal ductal structures accompanied by higher PTEN protein expression, as evident by H & E and PTEN staining (Figure 4C). This evidence concerns the gene PTEN and prostate intraepithelial neoplasia.