Results from our ChIP-Seq analysis identified oncogenic c-Myc, Cyclin D1, Ets2, Akt1 and Notch2, pro-inflammatory Hsp90, pro-lymphangiogenic VEGF-C, and pro-apoptotic p27 as novel transcriptional targets of MTA1, revealing its ability to simultaneously activate multiple tumor-promoting pathways. The gene discussed is NOTCH2; the disease is neoplasm.