Collectively, these data support a central role of MTA1 and MTA1-dependent signaling, including novel MTA1-Akt and MTA1-c-Myc feed-forward loops (Figure 2F), as significant drivers of Pten-loss induced prostate tumorigenesis and cancer progression suggesting potential benefits of MTA1-targeting approaches. The gene discussed is AKT1; the disease is male reproductive organ cancer.