CHD5 and renal cell carcinoma: Our semi-quantitative RT-PCR data showed that CHD5 was silenced or downregulated in 7/9 RCC, 2/3 prostate and 1/3 bladder tumor cell lines, but readily detected in most human normal adult tissues including kidney and prostate, as well as immortalized normal cell lines (HEK293 and RHEK-1) (Figure 1B and 1C, Supplementary Figure 1A).