The overall frequency of CHD5 methylation in TCGA RCC cohorts was 49% (334/688), with highest in ccRCC (100%, 320/320) [31], followed by papillary RCC (4.1%,12/292) and chromophobe RCC (3%, 2/66) [43] (Figure 2D). This evidence concerns the gene CHD5 and renal cell carcinoma.