Interestingly, RTqPCR quantification of GRIN2D expression within the endothelial compartment of the excised tumours endothelial cells demonstrated a 5.5-fold upregulation of expression within the mGRIN2D-Fc treated group compared to controls, when adjusted for endothelial isolation efficiency (p=0.0069, Mann-Whitney). The gene discussed is GRIN2D; the disease is neoplasm.