However, in contrast with the effect of NS1643 in breast cancer cells in which we detected an arrest of the cell cycle in G0/G1 phase, analyses of the cycle progression in A375 melanoma shows that stimulation of Kv11.3 channel significantly increased the population of cells in the G2/M phase compared to untreated cells (Figure 3B) suggesting that NS1643 determined an arrest of the cell cycle in the G2/M phase of the cell cycle. This evidence concerns the gene KCNH7 and breast carcinoma.