PTPN1 and colorectal carcinoma: For 234 patients, CRC as well as normal adjacent tissue was present on the TMA - in a paired analysis, PTP1B expression was shown to increase significantly within the same patient (2.7±0.1 versus 5.7±0.1, p<0.0001), suggesting a role for this phosphatase in the oncogenic transformation of IECs (Figure 3A).