Our findings discovered that exposure to gradient concentration of 4EGI-1 caused a profound loss of 4E-BP1 and eIF4E phosphorylation, both are likely required for the activation of DR5-caspase8 axis and subsequent killing of NPC cells, and 4EGI-1 enhanced the affinity of 4E-BP1 and eIF4E to bring down the translation efficiency of protein through repressing the phosphorylation of 4EBP1 and eIF4E. This evidence concerns the gene TNFRSF10B and nasopharyngeal carcinoma.