Positive expression of DR5 was identified in the cytoplasm and nuclei of NPC cells (Figure 1-A1 and 1-A3), DR4 staining was mainly located in cells cytoplasm, a few cases were also stained in cytoplasm and nucleus (Figure 1-B1 and 1-B3). This evidence concerns the gene TNFRSF10B and nasopharyngeal carcinoma.