Overexpression of FRG1 or its orthologs in mouse, Xenopus, and C. elegans inhibits myogenic cell migration, leads to defects in myogenic stem cells, disrupts muscle development and function, and recapitulates many features of FSHD [36–40], however the specific pathways leading to these phenotypes are not known. This evidence concerns the gene FRG1 and facioscapulohumeral muscular dystrophy.