As shown in Figure 4A and 4B, supernatants from IL-17A-treated ESCC cells (IL-17_EC109 and IL-17_KYSE30) showed significantly elevated chemotaxis effects on B cells than untreated cells (P = 0.015 and P = 0.012, respectively, Figure 4A and 4B). This evidence concerns the gene IL17A and esophageal squamous cell carcinoma.