After stratifying by age group, sex and cohort, carriers of one or two copies of p. 231V showed significantly delayed progression to clinical AIDS (dominant genetic model, RH = 0.68, 95% CI, 0.54–0.87, P = 0.002); In the model adjusted for the known genetic factors of HLA alleles (HLA-C, B27, B57, B35Px, HLA class I homozygosity, and CCR5 (p1 and Δ32)[31,32], the association remained significant (RH = 0.71, 95% CI, 0.56–0.91, Padj. = 0.007, Table 2). The gene discussed is CCR5; the disease is AIDS.