NNMT and familial pancreatic carcinoma: Bi HC, et al. [14] revealed that the sizes of xenograft tumors formed by PANC-1 cells (a human pancreatic cancer cell line) were inversely correlated with the levels of NNMT expression, whereas Yu T, et, al. reported that NNMT silencing and overexpression reduced and enhanced the malignancy of PANC-1 cells respectively [15].