We observed significant inverse associations between OPG expression and primary tumor size (P = 0.001), metastatic tumor size (P = 0.001), histological grade (P < 0.001), presence of nodal (P = 0.001) and hepatic (P < 0.001) metastases, occurrence of recurrent hepatic metastasis (P = 0.043), stage group (P = 0.003), and vascular invasion (P = 0.009). The gene discussed is TNFRSF11B; the disease is metastatic neoplasm.