TNFRSF11B and neoplasm: Pettersen and colleagues [12] and De Toni and colleagues [7] observed the expression of OPG mRNA and proteins in CRC cell lines, Tsukamoto and colleagues [13] reported a significant correlation between OPG expression and aggressive behavior of CRC including depth of invasion and distant metastasis and worse survival rates; they identified OPG overexpression as an independent predictive factor for tumor recurrence.