Univariate analysis for survival showed that presence of nodal metastasis (P = 0.002), recurrence of hepatic metastasis (P = 0.005), higher stage group (P < 0.001), presence of lymphatic (P < 0.001) and/or vascular invasion (P < 0.001), multiplicity of metastatic tumors (P < 0.001), and reduced OPG expression (P = 0.016) were significant predictors of poor prognosis (Table 5). The gene discussed is TNFRSF11B; the disease is metastatic neoplasm.