As one of the isoforms in the protein kinase C (PKC) family, PKC beta (PKC β) is overexpressed in several solid tumors, including colon cancer, breast cancer, and neuroblastoma, as well as in lymphoid malignancies, including refractory diffuse large B-cell lymphoma (DLBCL), chronic lymphocytic leukemia and follicular lymphoma. Here, PRKCB is linked to diffuse large B-cell lymphoma.