Knop et al. suggested that fasting hyperglucagonemia develops before glucose intolerance and the development of T2DM [9], and that high fasting glucagon levels exacerbate postprandial hyperglycemia and, as a consequence, could induce an increase in plasma insulin and subsequent hyperinsulinemia as well as insulin resistance [42]. The gene discussed is INS; the disease is type 2 diabetes mellitus.