However, our data revealing that the outcome of Fas signaling is determined by its pY status of the death domain and that the Fas pY status may differ among different cancer types and may respond to anticancer treatment provide a basis for further studies in larger sets of human cancer samples, as well as an opportunity to develop a practical means to predict the outcome of Fas signaling in different pathologies that can lead to the use of Fas pY screening to aid Fas-related therapeutic design and maximize the chance of therapeutic success. Here, FAS is linked to cancer.