PLAT and hypertensive disorder: Correction for age, sex and 24-hour MAP also gave a significant association between tPA-activity and pWMH progression (OR 2.34, 95% CI 1.03–5.34), and the results were similar with correction for sex, age and any of the cardiovascular risk factors (including hypertension), as well as with correction for age, sex and the presence of extensive pWMH at baseline (OR 2.36, 95% CI 1.01–5.49).