Different genetic risk factorsare associated with both sporadic and late onset AD (cases 65 and older).Candidate genes include A2M (encoding alpha-2-macroglobulin),ABCA1 and 2 (encoding ATP-binding cassettetransporters 1 and 2, respectively), CLU (encoding clusterin),PICALM (encoding the phosphatidylinositol binding clathrinassembly protein), SORL1 (encoding sortilin-related receptorgene), and TREM2 (triggering receptor expressed on myeloidcells 2) [7]. The gene discussed is CLU; the disease is Alzheimer disease.