The interaction of AGEs with their cell surface receptor (RAGE) has been shown to play a role in the pathogenesis of various devastating disorders [37] such as cancers [21, 38–42], Alzheimer's disease [43, 44], insulin resistance [45], diabetes and its complications including micro- and macrovascular disease, retinopathy [46], neuropathy, and nephropathy [47, 48], liver cirrhosis [49, 50], and nonalcoholic steatohepatitis (NASH) [16, 17, 51]. Here, CD177 is linked to metabolic dysfunction-associated steatohepatitis.