The Avoiding Cardiovascular Events through Combination Therapy in Patients Living with Systolic Hypertension (ACCOMPLISH) trial (35) explored the hypothesis that treatment of hypertensive patients, at a risk of cardiovascular disease was better with a combination of an angiotensin converting enzyme inhibitor (benazepril) and a calcium channel blocker (amlodipine) than a combination of an ACE inhibitor (benazepril) and a diuretic (hydrochlorothiazide) as recommended by then prevailing JNC 7 guidelines. This evidence concerns the gene ACE and cardiovascular disorder.