Further, treatment of the MiaPaca2 pancreatic cancer cell line with the p38 inhibitor SB203580 caused an increase in VHL-HIF-1α binding (Kwon et al., 2005) suggesting that p38 contributes to HIF-1α stabilization, though no half-life measurements were performed. The gene discussed is MAPK14; the disease is familial pancreatic carcinoma.