To assess the effect of SCD status on indicators and parameters associated with iron homeostasis (22, 28, 29), we compared the concentration of four serum iron proteins (transferrin, ferritin, sTfR, and hepcidin) and the log (sTfR)/log (ferritin) index between SCD subjects and controls. The gene discussed is TFRC; the disease is Schnyder corneal dystrophy.