A human patient-derived induced pluripotent stem cell (iPSC) model of Rett Syndrome expressing a de novo frame-shift mutation in exon 4 (c.806delG) illustrated a parallel role for MeCP2 in the promotion of neural identity in which neural stem cells lacking MeCP2 exhibited increased astrocytic differentiation in vitro [56]. The gene discussed is MECP2; the disease is atypical Rett syndrome.