GSK3B and Alzheimer disease: In AD, the neuropathological characteristics of the formation of senile plaques by Aβ is associated with the chronic inflammation involving reactivated astrocytes, microglia, and proinflammatory molecules such as IL-1β, TNF-α, human CCAAT/enhancer-binding protein (CEBP) delta (CEBPD), p38MAPK, and GSK3β.