As a newly identified nonselective Ca2+-permeable cation channel and the sensor of reactive oxygen species (ROS), transient receptor potential melastatin member 2 (TRPM2) channel has recently been indicated to be involved in inflammatory/neuropathic pain, synaptic plasticity, oxidative stress, and neurodegenerative diseases through modulation of multiple signaling pathways [17–20]. Here, TRPM2 is linked to neurodegenerative disease.