In addition, the Ca2+ signaling induced by lipopolysaccharide and interferon gamma (LPS/IFNγ) in microglia is absent by pharmacological blockade or gene deletion of TRPM2 channel [28] while deletion of TRPM2 channel attenuates the activation of spinal microglia in the neuropathic pain model with peripheral nerve injury [22, 23]. This evidence concerns the gene TRPM2 and peripheral nerve injury.