Studies have shown that FoxM1 plays a critical role in not only tumor metastasis, EMT, cell motility, invasion, and premetastatic niche formation [33] but other key cancer hallmarks as well (Figure 1)—reprogramming of energy metabolism; promotion of genomic instability [34, 35], inflammation, cell proliferation, and angiogenesis; evasion of growth/tumor suppression; circumvention of apoptosis; and enabling of replicative mortality [29]. This evidence concerns the gene FOXM1 and neoplasm.