LATS1 and neoplasm: Therefore, we focused on LATS1 and LATS2 genes which are the common tumor suppressor genes in the UV-induced DNA Damage Response (DDR) signaling pathways. Lats (large tumor suppressor) gene, a Ser/Thr kinase, belongs to the Ndr/LATS subfamily of AGC (protein kinase A/PKG/PKC) kinases originally isolated from Drosophila melanogaster.