STAT3 and neoplasm: CK induced apoptosis in several tumor cell lines by regulating various signaling pathways, such as the activation of caspase-8 [59] and AMP-activated protein kinase (AMPK) [60,61], suppression of nuclear factor-kappa B (NF-кB) pathways [62] and Janus activated kinase 1 (JAK1)-signal transducer and activator of transcription 3 (STAT3) signaling [63].