Differential expression of glycosaminoglycans and proteoglycans has pathogenic significance, since decorin may modulate the bioactivity of TGF-β1, thus directly affecting the entity of peritoneal fibrosis, whereas hyaluronan fragments have been shown to induce multiple signaling cascades, cytokine secretion, and matrix metalloproteases (MMP) activity [26]. Here, TGFB1 is linked to Peritoneal Fibrosis.