With respect to hepatic fibrosis, PPARγ plays a central role in the activation of HSCs, as PPARγ expression alone is enough to restore the quiescent phenotype in activated HSCs (Hazra et al., 2004) and both activation and proliferation of HSCs correspond to exhausted PPARγ expression (Zhang et al., 2013). This evidence concerns the gene PPARG and Hepatic fibrosis.