ACTA1 and Hepatic fibrosis: Fibrotic rats only once treated with a plasmid-containing liposomes by means of retrograde intrabiliary infusion exhibited a rise of HGF gene expression and a simultaneous reduction of the fibrotic markers α-SMA, TGF-β1, and collagen type I, resulting in regression of hepatic fibrosis (Narmada et al., 2013).