CREBBP and ocular melanoma: An antifibrotic effect has been studied in rats with CCl4-induced liver fibrosis, since OM potently limits the production as well as deposition of collagen, probably by upregulation of SMAD7 and downregulation of SMAD3 and CREBBP (CREB binding protein) gene expression, thus interfering with the canonical TGF-β1 signaling pathway (Wu et al., 2008).