Besides AD, NFTs composed of hyperphosphorylated tau was found to be a common pathological feature in a number of neurodegenerative disorders including Parkinson’s disease, frontotemporal dementia and progressive supranuclear palsy (PSP), referring as a class of neurodegenerative diseases called tauopathies (Spillantini and Goedert, 1998; Lonskaya et al., 2014; Golovyashkina et al., 2015; Yamada et al., 2015). This evidence concerns the gene MAPT and Alzheimer disease.