In relation to reelin expression in plasma and membrane protein clustering in depression, it is also of interest to consider that alterations in the pattern of clustering appear to affect proteins that tend to integrate within lipid rafts, such as the serotonin transporter (Magnani et al., 2004), and that shifting of Gα-proteins to and from lipid raft domains has been postulated as a possible mechanism involved in the chronic effects of antidepressants (Zhang and Rasenick, 2010; Czysz et al., 2015). The gene discussed is RELN; the disease is major depressive disorder.