The addition of exogenous reelin also prevents hippocampal dentate granule cell dispersion in experimental epilepsy (Müller et al., 2009), has a preventive effect on phencyclidine-induced behavioral deficits (Ishii et al., 2015), and recovers the neurochemical and behavioral phenotype in a mouse model for Angelman syndrome (Hethorn et al., 2015). This evidence concerns the gene RELN and Angelman syndrome.