RELN and major depressive disorder: One example if this is the fact that both stress and deficient reelin can impair adult hippocampal neurogenesis and the proper maturation and integration of newborn neurons in the dentate gyrus (Pujadas et al., 2010; Lussier et al., 2013a), which have been repeatedly implicated in the pathogenesis of depression (as a recent review, see Schoenfeld and Cameron, 2015).