The generalized up-regulation of the potent transcriptional activator NF-kB in AD brain was therefore somewhat perplexing since NF-kB is known as a strong inducer of inflammatory gene expression (Lukiw and Bazan, 1998; Lukiw et al., 2008; Cui et al., 2010; Devier et al., 2015; Kaur et al., 2015; Srinivasan and Lahiri, 2015). Here, NFKB1 is linked to Alzheimer disease.