Interestingly most of the up-regulated pathogenic, pro-inflammatory genes in sporadic AD brain are directly under NF-kB transcriptional control, while down-regulated mRNAs and their expression appear to be under negative regulatory control by miRNAs which have NF-kB regulatory sites in their promoters (Figure 1; Lukiw and Bazan, 1998; Lukiw et al., 2008; Cui et al., 2010; Lukiw, 2012a,b, 2013a; Devier et al., 2015; Kaur et al., 2015; Srinivasan and Lahiri, 2015). The gene discussed is NFKB1; the disease is Alzheimer disease.