In summary, the identified DEGs and their related miRNAs, especially miRNA-200c and its target genes COL5A2 as well as COL5A3, miRNA-15a and its target genes ATP6V0B and miRNA-155 may play key roles in the progression of ccRCC, and these may be useful biomarkers for predicting tumor metastasis and therapeutic targets for the treatment of ccRCC. The gene discussed is COL5A3; the disease is neoplasm.