The colonization might be associated with acute wheezing episodes [58], but even if asymptomatic in infancy, children diagnosed with asthma at the age of 7 years still exhibited excessive immune responses with the aberrant production of IL-5, IL-13, IL-17, and IL-10 by their PBMCs when treated with those pathogens that had colonized them during their infancy [59]. The gene discussed is IL17A; the disease is asthma.