Investigating the different subclasses of AMLA and AFA, patients with pericardial disease had significantly higher AFA-IgG levels in the pericardial fluid and significantly higher AFA-IgM and AFA-IgA levels in serum compared with the control group (p = 0,04 and p = 0,003, resp). This evidence concerns the gene CD40LG and ankyloblepharon filiforme adnatum-cleft palate syndrome.