In the whole sample of subjects including the controls and all the AD continuum groups, increased CSF sTREM2 was associated with higher levels of T‐tau (β = +0.336, P = 0.001) (Fig 3A and B) and P‐tau181P (β = +0.370, P = 0.001) (Fig 3C and D), and lower levels of Aβ1–42 (β = −0.098, P = 0.014) (Fig 3E and F). Here, MAPT is linked to Alzheimer disease.