Pathway analysis of the 441 upregulated mRNAs denoted their involvement in IL23-mediated signaling events, IFN-γ signaling, the NF-κB signaling pathway, chemokine receptor binding of chemokines, GPCR ligand binding, and metabolic disorders of biological oxidation enzymes (Fig. 5a). The gene discussed is NFKB1; the disease is metabolic disease.