DCN and colorectal carcinoma: CRC ECM was characterized by a down-modulation of i) basal membrane proteins such as Laminin subunit beta-2 and Nidogen-1, and ii) interstitial matrix proteins (Matrilin-2, full-lenght and isoform 4 of Collagen 6A3, and Mimecan), for some of which (Decorin and Dermatopontin) anti-proliferative activity was previously demonstrated (described in section 4 of Supplementary Material 1).