Stroke was significantly associated with GnRH alone (HR = 1.20; 95 % CI 1.12–1.28; P < 0.001), GnRH plus AA (HR = 1.23; 95 % CI 1.13-1.34; P < 0.001), and orchiectomy (HR = 1.37; 95 % CI 1.33–1.64; P = 0.001), but not with AA alone (HR = 1.06; 95 % CI 0.71–1.57; P = 0.78). The gene discussed is GNRH1; the disease is Stroke.