MAPT and Alzheimer disease: Immunohistochemical analyses of human AD brains have so far revealed the presence of three acetylated forms of hTau within Tau deposits, namely acetylated-K174-hTau, acetylated-K274-hTau and acetylated-K280-hTau, suggesting a high biological relevance of these modified epitopes in AD pathogenesis2, 5, 7, 8.