CDKN2A and neoplasm: However, given that up to 92.9 and 60 % of the patients with p16INK4a-positive tumours had detectable levels of HPV-16 DNA and RNA respectively in their oral fluid, as well as the lack of false positive in the p16INK4a-negative patients, strongly indicate that p16INK4a positivity in tumour is associated with HPV-16 infection in the current study.