When osteocalcin was entered as a dependent variable and waist circumference, diabetes duration, menopause duration, insulin, triglycerides, femoral and lumbar BMD, and therapy, as independent variables, the strongest predictors of osteocalcin were L-BMD, insulin and pyrilinks, R2 = 0,420, p = 0,000001 (data not shown). This evidence concerns the gene BGLAP and diabetes mellitus.