If we look at PAI-1 levels in our study, a decreased concentration was observed in diabetic female subjects with lower bone mineral density (the difference being greatest between osteoporosis and normal BMD group) along with positive correlation with lumbar and femoral BMD and negative one with bone turnover markers, suggesting that increased leves of PAI-1 could protect against bone loss in diabetes type 2 female patients. This evidence concerns the gene SERPINE1 and type 2 diabetes mellitus.