PAI-1 positively correlated with lumbar BMD (p < 0,05) and proximal femur BMD (p < 0,000) as well as BMI (p < 0,000), insulin (p < 0,000) and triglycerides (p < 0,000) while negative correlation was observed in relation to age (p < 0,01), HDL cholesterol (p < 0,001), diabetes duration (p < 0,002), beta cross laps (p < 0,002), pyrilinks (p < 0,002) and osteocalcin (p < 0,002) (Table 2). The gene discussed is INS; the disease is diabetes mellitus.