CTSB and neoplasm: Vascular Endothelial Growth Factor (VEGF) promotes angiogenesis, pentraxin-3 is a pattern recognition molecule mediating inflammatory responses, cathepsin-B protease is often linked to tumor invasion and metastasis while Nitric oxide synthase 2 (inducible NOS-2) causes inflammation by synthesis of reactive free radical Nitric Oxide (NO).