We showed that NFκB inhibitors-5-Aminosalicylic acid (ASA) and BAY-11 (BAY) and PKC inhibitors-UCN-01 (UCN) and staurosporin (STS) effectively reduced MMP activity in LN-18 and G-1 cells confirming the role of NFκB and PKC-α signaling during tumor invasion. This evidence concerns the gene PRKCA and neoplasm.