SIRT1 and neoplasm: In the present study, we hypothesized that SIRT1/2 was critical in controlling the destiny of bulk tumor cells and cancer stem cells (CSCs) of UM, and that inhibiting SIRT1/2 by Tenovin-6 might result in apoptosis in UM cells by releasing expression of tumor suppressor genes such as p53 and elevating reactive oxygen species (ROS).