In particular: 1) NLRP3/PYCARD, NLRP1/PYCARD and NLRP3/caspase1 co-localization was increased in both groups of AD patients compared to HC and MCI; 2), NLRP3/caspase8 and NLRP1/caspase5 co-localization was increased in severe AD alone; and 3) NLRP1/caspase1 co-localization was seen only in cells of MILD AD individuals. This evidence concerns the gene PYCARD and Alzheimer disease.