In particular, the observation that some (NLRP1, NLRP3) but not not all (PYCARD, caspase 1) of the genes necessary for the assembly of an inflammosome complex genes are upregulated in MCI suggests that monitoring the transcription rate of, e.g. PYCARD in MCI could offer an early diagnostic tool for AD development. This evidence concerns the gene PYCARD and Alzheimer disease.