Peripheral CD14+ monocytes that express NLRP3 or co-express NLRP3 and PYCARD, NLRP3 and caspase 1, or NLRP3 and caspase 8 were augmented in LPS-primed and Aβ42−stimulated-cells of both groups of AD patients compared to MCI individuals and HC. Here, PYCARD is linked to Alzheimer disease.