LPS-primed and Aβ42-stimulated NLRP1-expressing CD14 cells were significantly increased as well in both groups of AD patients compared to MCI and HC (p <0.05), while CD14+/NLRP1+/PYCARD + and CD14+/NLRP1+/caspase1+ immune cells were augmented, although not significantly, in AD patients compared to other two groups. The gene discussed is PYCARD; the disease is Alzheimer disease.