Results showed that 1) CD14+/NLRP3+, CD14+/NLRP3+/caspase1+, and CD14+/NLRP3+/Caspase8+ immune cells were significantly increased in severe AD patients alone compared to MCI and HC (p <0.05) and 2) CD14+/NLRP3+/PYCARD +, cells were augmented both in severe and MILD AD compared to MCI and HC (MCI and HC vs. moderate AD p <0.05; vs. severe AD p <0.01)(Fig. 4a). The gene discussed is NLRP3; the disease is Alzheimer disease.