Because FACS and confocal microscopy data indicated that the different subunits that compose the inflammasome do aggregate in LPS-primed and Aβ42−-stimulated- monocytes of AD patients, and PCR analyses showed that mRNA for these cytokines is increased in monocytes of AD patients, IL-1β, IL-18, IL-33 and IL-37 were next measured. The gene discussed is IL18; the disease is Alzheimer disease.