NLRP3 and Alzheimer disease: Results of mRNA expression confirmed that: 1) NLRP1, NLRP3 and caspase 8 are significantly increased in AD and MCI individuals compared to HC (p <0.05), with the highest values observed in severe AD, and 2) PYCARD, caspase 1 and caspase 5 are significantly increased in AD compared to MCI and HC (p <0.05) (Fig. 2a).