To summarize: 1) the expression of NLRP1, NLRP3 and caspase 8 was greatly increased in all groups of patients (nFold >10) compared to HC, with no detectable differences being observed between individuals with a diagnosis of AD or MCI; and 2) PYCARD, caspase 1 and caspase 5 expression was increased in AD (nFold ≥10) but not in MCI individuals. Here, PYCARD is linked to Alzheimer disease.