In the present study, we demonstrate that for SCO-induced amnesia in a mouse model, FSJ has potent anti-amnesic effects that may be mediated by improving hippocampal neurogenesis and cognitive functioning, restoring the hippocampal cholinergic system, and up-regulating the hippocampal pathway involving BDNF, CREB, and Akt signaling. Here, CREB1 is linked to amnesia.