Computational analysis of the transcript sequences provided a lead for its post-transcriptional regulation; namely the alternative splice site at the 5' UTR region, and the hairpin structure of the flanking region, are enriched with putative RBP binding domains, and thus in breast cancer PRICKLE1 function may be regulated by alternative RBP binding abilities due to alternative stem-loop structures in the 5’ UTR. Here, PRICKLE1 is linked to breast cancer.