Gene cluster B was highly enriched with genes of extracellular matrix and/or genes that regulate signal transduction pathways for Epithelial-to-Mesenchymal transition (EMT), including RBFOX2 (RBM9), which has been demonstrated to regulate the EMT splicing in a panel of breast cancer cell lines and primary tumors [28, 29]. The gene discussed is RBFOX2; the disease is breast cancer.